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Search Results for " ALK 2 "

ターゲット

阻害剤

309

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T10287	ALK2-IN-2		ALK , TGF-beta/Smad
	ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.		ALK , TGF-beta/Smad
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T39764	KER047	ALK2-IN-4	ALK
	KER047 (ALK2-IN-4) is an ALK2 inhibitor with potential anticancer activity and can be used in the study of non-small cell lung cancer.		ALK
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T2655	CEP-37440	CEP37440	FAK , ALK
	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).		FAK , ALK
T79393	ALK/EGFR-IN-2
	ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines...
T2251	NVP-TAE 684	TAE684	Apoptosis , ALK
	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).		Apoptosis , ALK
T67699L	ALK/ROS1 inhibitor 2e HCL	(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)	Apoptosis
	ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.		Apoptosis
T40065	ALK2-IN-4 succinate	ALK2-IN-4 succinate
	ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2.
T15612	JH-VIII-157-02		Microtubule Associated , ALK
	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L...		Microtubule Associated , ALK
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T77726	INCB-000928		ALK
	Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.		ALK
T3079	GSK1838705A		IGF-1R , JNK , S6 Kinase , ALK
	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.		IGF-1R , JNK , S6 Kinase , ALK
T62546	ALK5-IN-27
	ALK5-IN-27 (Compound EX-04) is a potent inhibitor of ALK-5 (IC50 ≤ 10 nM). ALK5-IN-27 also inhibits ALK-2.
T62393	ALK5-IN-25
	ALK5-IN-25 (compound EX-02) is a potent inhibitor of ALK-5 (IC50<10 nM) and also inhibits ALK-2. ALK5-IN-25 can be used in cancer research.
T13139	TP-008	TGFβRI-IN-2	Others
	TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively).		Others

Compounds

Target: ALK, TGF-beta/Smad

ALK inhibitor 1

T10285

Synonym:

Target: FAK, IGF-1R, ALK

Target: Apoptosis, ALK

ALK/ROS1 inhibitor 2e HCL

T67699L

Synonym: (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)

Target: Apoptosis

ALK2-IN-4 succinate

T40065

Synonym: ALK2-IN-4 succinate

Target: Microtubule Associated, ALK

ALK-IN-1

T3059

Synonym: AP26113,Brigatinib,AP26113-analog

Target: EGFR, IGF-1R, ALK

Target: IGF-1R, JNK, S6 Kinase, ALK

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04774	ALK-2/ACVR1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	ALK-2/ACVR1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.8kDa and the accession number is Q04771.
TMPY-01096	ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293 Cells
	ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 40 kDa and the accession number is P37172.
TMPJ-01158	ALK-2/ACVR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formati...
TMPY-01168	ALK-1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.
TMPY-00658	ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is D3DPA4.
TMPY-01059	BMPR2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873.
TMPH-00915	ALKAL2 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	ALKAL2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli.
TMPH-00914	ALKAL2 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	ALKAL2 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPY-03706	ALK-2/ACVR1 Protein, Canine, Recombinant (hFc)	Canine	HEK293 Cells
	ALK-2/ACVR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.6 kDa and the accession number is A0A8C0MPL7.
TMPY-03157	ALK-2/ACVR1 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	ALK-2/ACVR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.5 kDa and the accession number is P80201.
TMPY-00650	ALK-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310.
TMPY-03247	ALK-2/ACVR1 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	ALK-2/ACVR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is F7A9J8.
TMPY-03707	ALK-2/ACVR1 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	ALK-2/ACVR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is A0A8C0MPL7.
TMPY-05483	ALK-4/ACVR1B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ALK-4/ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1.
TMPY-01293	ALK-4/ACVR1B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ALK-4/ACVR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P36896-1.
TMPY-00683	BMPR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	BMPR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is Q13873.
TMPY-02172	Midkine Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, h...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293 Cells
	Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
TMPY-00871	LAYN Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LAYN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q6UX15-2.
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149)	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2.
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-00849	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.
TMPY-00850	ST2/IL-1 RL1 Protein, Human, Recombinant	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
TMPY-02358	CD98 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CD98 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P10852-2.
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293 Cells
	Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293 Cells
	FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-02367	Neuropilin-1 Protein, Human, Recombinant (isoform b, His)	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2.
TMPY-01199	CD74 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a)	Human	E. coli
	SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-05427	CD19 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2.
TMPY-01359	ST2/IL-1 RL1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2.
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-04829	G-CSF Protein, Human, Recombinant	Human	HEK293 Cells
	G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
TMPY-02096	TACI Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2.
TMPY-04844	BTN3A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.
TMPY-01935	C-Kit Protein, Human, Recombinant (His)	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-01985	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2.
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	HEK293 Cells
	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
TMPY-00127	M-CSF/CSF1 Protein, Human, Recombinant	Human	HEK293 Cells
	M-CSF/CSF1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.4 kDa and the accession number is P09603-2.
TMPJ-00335	TGFBR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
TMPY-01871	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)	Human	HEK293 Cells
	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
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